Fig. 6
From: Oxidative stress tolerance contributes to heterologous protein production in Pichia pastoris
Expression levels of key genes. Comparative of the robust mutant with the wild type under identical methanol conditions. AOX1: alcohol oxidase 1; Form, formaldehyde; DAS1, dihydroxyacetone synthase; DHA: dihydroxyacetone; DHAP: dihydroxyacetone phosphate; E4P: erythrose-4-phosphate; FBA1-2: fructose 1,6-bisphosphate aldolase; FDH1: formate dehydrogenase 1; Form, formaldehyde; F1,6BP: fructose 1,6-bisphosphate; F6P: fructose-6-phosphate; GAP: glyceraldehyde-3-phosphate; R5P: ribose-5-phosphate; Rul5P: ribulose-5-phosphate; S1,7BP: sedoheptulose-1,7-bisphosphate; S7P: sedoheptulose-7-phosphate; X5P: xylulose-5-phosphate; GS-CH2OH: S-(hydroxymethyl)glutathione; GS-CHO: S-formylglutathione; HCOOH: formic acid; G6P: glucose-6-phosphate; FDP: fructose-1, 6-diphosphate; PEP: phosphoenolpyruvate; OAA: oxaloacetic acid; TCA: tricarboxylic acid cycle. *p < 0.05, **p < 0.01, ***p < 0.001