Fig. 4

Plot giving a comparative view of the target suggestions from 8 independent runs of the evolutionary algorithm. Each of the eight grey circles corresponds to the results of one replicate run, and dots on these circles indicate which reactions were targeted in the given run. The IDs of the reactions targeted are shown on the outside (see Table 6 for corresponding reactions). Green and red dots indicate targets for up- and down-regulation, respectively. The sectors indicate the areas of metabolism that were targeted