Integration of Aspergillus niger transcriptomic profile with metabolic model identifies potential targets to optimise citric acid production from lignocellulosic hydrolysate

Table 4 Input/output fluxes in iDU1327 at selected timepoints without constraint on citric output

Input/output reaction	T1 flux (mmol gDW⁻¹ h⁻¹)	T2 flux (mmol gDW⁻¹ h⁻¹)	T3 flux (mmol gDW⁻¹ h⁻¹)
Glucose (DGLCe <==>)	− 1.2552	− 0.4392	0.0
Xylose (XYLe <==>)	− 0.0718	− 0.0647	− 0.1936
External phosphate (PIe <==>)	− 0.1455	0.0	0.0
Internal phosphate (PI <==>)	0.1339	− 0.0019	− 0.00005
Biomass	0.1207 (h⁻¹)	0.0195 (h⁻¹)	0.0006 (h⁻¹)
Citric acid (CIT-e <==>)	0.0	0.3159	0.135
Carbon dioxide (CO₂e <==>)	3.3671	0.3311	0.137
Oxygen (O₂e <==>)	− 1.9835	− 0.581	− 0.3331

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