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Table 1 Selected genes associated with the depletion of reduced coenzymes in the TCA cycle

From: Improved energy efficiency in microbial fuel cells by bioethanol and electricity co-generation

Gene name

Pathway

Reaction

Dependency

mae

TCA cycle

(S)-malate + NAD+  → CO2 + pyruvate + NADH

NAD-dependent enzyme

idp1, idp2, idp3

Glutamate biosynthesis

D-threo-isocitrate + NADP+ \(\leftrightarrow\) 2-oxoglutarate + CO2 + NADPH (reversible)

NADP-dependent enzyme

mdh1, mdh2, mdh3

TCA cycle

(S)-malate + NAD+ \(\leftrightarrow\) oxaloacetate + NADH + H+ (reversible)

NAD-dependent enzyme

oye2, oye3

Sterol metabolism, citronellol synthesis

Oxidized electron acceptor + NADPH + H+ \(\leftrightarrow\) reduced electron acceptor + NADP+(reversible)

NADPH-dependent enzyme