Table 6 Available crystal structures of 2-dehydro-3-deoxy-d-gluconate aldolases with reported 2-dehydro-3-deoxy-aldopentonate activity

2-Dehydro-3-deoxy-d-gluconate aldolase (Ss KDGA) EC 4.1.2.51

1W37

1W3I

1W3N

1W3T

6G3Z

Saccharolobus solfataricus

2.00

1.70

2.10

2.10

2.35

–

Pyruvate

2-keto-3-deoxy-d-gluconate

2-keto-3-deoxy-d-galactonate, d-glyceraldehyde, pyruvate

2-keto-3-deoxy-6-phosphogluconate

Tetramer

[91, 94]

2-Dehydro-3-deoxy-d-gluconate aldolase

(Sa KDGA)

EC 4.1.2.51

2NUW

2NUX

2NUY

Sulfolobus acidocaldarius

1.80

2.50

2.50

–

–

Pyruvate

Tetramer

[89]

2-Dehydro-3-deoxy-d-gluconate aldolase (Ec KDGA)

EC 4.1.2.51

2V8Z

2V9D

3N2X

3NEV

4OE7

4ONV

4PTN

4U4M

Escherichia coli

2.20

2.15

2.20

2.19

1.99

2.57

1.99

3.09

–

–

Pyruvate

2-keto-3-deoxy-d-galactonate

4-hydroxy-2,5-DOP, pyruvate, ethanedial, Mg²⁺

2-keto-3-deoxy-d-gluconate

l-glyceraldehyde, Mg²⁺

pyruvate

Tetramer

[92, 93, 95,96,97,98]