Fig. 1

Transcriptional analysis of sZJD-28 and CEN.PK113-11C. a Gene sets with significant differences in sZJD-28 compared with CEN.PK113-11C. GO terms are colored according to their ranking, and each cell of the heatmap includes the significance of the GO terms. Dist (dn) is distinct-directional down, representing this gene set is coordinately down-regulated. Dist (up) is distinct-directional up, representing this gene set is coordinately up-regulated. Mix (dn) is mixed directional down and Mix (up) is mix-directional up, separately providing the significance of subsets of up- and downregulated genes in a gene set. Nondir is non-directional change, providing gene set p values obtained by omitting the direction of differential expression [13]. b Transcriptional level of genes related to oxidative phosphorylation (OXPHOS) in sZJD-28 compared with CEN.PK113-11C. c Schematic representation of the differential transcriptional changes of genes involved in the glycolysis, tricarboxylic acid (TCA) cycle, mevalonate (MVA) pathway, pentose phosphate pathway (PPP), fatty acid synthesis and shikimate pathway. Color keys demonstrate transcriptional fold changes in sZJD-28 relative to CEN.PK113-11C