Fig. 2

Comparative transcriptomic analysis of strains ΔlaeA and WT grown on glucose. a Differential expression analysis of ∆laeA in comparison to WT when growth on 2% glucose for 24 h. Log2 ratio of ∆laeA/WT vs. maximum RPKM in either strain. Genes exhibiting differential expression levels are plotted in red. b KEGG analysis of the 337 genes with up-regulated expression levels in strain ∆laeA on glucose. c Hierarchical clustering of expression profiles of 26 transcription factor genes. Growth phenotype of mutants in N. crassa are from ref. [35]. d Cell dry weight of M. thermophila strains Δcre-1, Δgrf-1, Δgrf-2, and Δgrf-3, after growth on glucose for 36 h. e Cell dry weight of double mutants ∆laeAΔcre1, ∆laeAΔgrf-1, ∆laeAΔgrf-2, and ∆laeAΔgrf-3 after growth on glucose for 36 h. Detailed data for a, b, and c are shown in Additional file 1: Tables S3, S4, and S6, respectively. * depicts p value < 0.05; ** depicts p value < 0.01 and *** depicts p value < 0.001