Fig. 1

The engineering strategies for de novo production of 2-phenylethanol by C. glutamicum. The red arrows indicated that pathways were overexpressed. Metabolites: G6P, glucose-6-phosphate; F6P, fructose-6-phosphate; GAP, glyceraldehyde-3-phosphate;PEP, phosphoenolpyruvate; PYR, pyruvate; OAA, oxaloacetate; CIT, citrate; AcCoA, Acetyl-CoA; Ru5P, ribulose-5P; X5P, xylulose-5P; R5P, ribose-5P; S7P, sedoheptulose‑7‑phosphate; E4P, erythrose‑4‑phosphate; DAHP, 3-deoxy-D-arabinoheptulosonate 7-phosphate; DHQ, 3-dehydroquinate; DHS, 3-dehydroshikimate; SA, shikimate; S3P, Shikimate-3-phosphate; EPSP, 5-enolpyruvyl shikimate 3-phosphate; CHA, chorismate; PPA, prephenate; PPY, phenylpyruvate; PPAL, phenylacetaldehyde. Genes/enzymes: pts, phosphoenolpyruvate phosphotransferase system; xylE, xylose transporter; xylA xylose isomerase; xylB, xylulokinase; tkt, transketolase; tal, transaldolase; aroG, DAHP synthase; ppsA, phosphoenolpyruvate synthase; aroL, shikimate kinase II; aroA, 5-enolpyruvylshikimate-3-phosphate synthetase; pheA, chorismate mutase-prephenate dehydratase; aro10, 2-ketoisovalerate decarboxylase; yahK, alcohol dehydrogenase