Microbial tolerance engineering for boosting lactic acid production from lignocellulose

Table 2 Strain tolerance modification based on random mutagenesis

	Against inhibitors	Products	Microorganism	References
UV mutagenesis following adaptation	Acetic acid, furfural and vanillin	Ethanol	Scheffersomyces stipitis	[60]
UV mutagenesis	Furfural	Ethanol	Spathaspora passalidarum	[61]
UV mutagenesis	Acetic acid and furfural	Ethanol	Scheffersomyces shehatae	[62]
UV mutagenesis	Acetic acid and HMF	Ethanol	Pichia stipitis	[63]
Low-energy ion implantation	p-coumaric acid, ferulic acid, 4-hydroxybutyl acrylate, vanillic acid, syringaldehyde	Acetone/butanol/ethanol	Clostridium beijerinckii	[64]
ARTP following adaptation	Furfural, HMF, vanillin, syringaldehyde and p-hydroxybenzaldehyde	LA	B. coagulans	[59]
ARTP	Formic acid, acetic acid, levulinic acid, HMF, vanillin	Lipid	Rhodosporidium toruloides	[65]
Multiplex ARTP	Acetic acid	Ethanol	Z. mobilis	[12]

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