Fig. 9
From: The Ras small GTPase RSR1 regulates cellulase production in Trichoderma reesei
Putative mechanism for RSR1 regulating cellulase production in T. reesei. GPCRs are shaded in green, ACY1-cAMP-PKA pathway in blue, cellulose molecule in purple, cellulase gene in red, and RSR1 in yellow. Positive regulation is represented by a solid line with arrowheads. Negative regulation is represented by a line ending in a vertical line. Dotted arrows in both directions represent unknown connections. The solid arrows indicate data supported by our results, and the dashed arrows indicate undefined regulation. After receiving signal stimulation from extracellular cellulose molecules, three GPCRs on the membrane may transmit signals to RSR1, promoting the expression of ACY1-cAMP-PKA pathway-related genes, increasing intracellular cAMP content, negatively regulating the expression of ACE3 and XYR1, promoting the expression of CRE1, and ultimately repressing cellulase production