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Fig. 1 | Biotechnology for Biofuels and Bioproducts

Fig. 1

From: Construction of a plasmid-free l-leucine overproducing Escherichia coli strain through reprogramming of the metabolic flux

Fig. 1

l-leucine biosynthesis pathway of Escherichia coli, and metabolic strategies for increasing the yield. G-6-P, glucose-6-phosphate; PEP, phosphoenol-pyruvic acid; Pyr, Pyruvate; SUCC, Succinate; ICI, Citrate; ilvIH, acetolactate synthase; ilvC, ketol-acid reductoisomerase; ilvD, dihydroxy-acid dehydratase; ilvE, branched-chain amino-acid aminotransferase; leuA, 2-isopropylmalate synthase; leuB, 3-isopropylmalate dehydrogenase; leuC, 3-isopropylmalate dehydratase subunit LeuC; leuD, 3-isopropylmalate dehydratase subunit LeuD; pntA, pyridine nucleotide transhydrogenase subunit alpha; pntB, pyridine nucleotide transhydrogenase subunit beta; Bcldh, l-leucine dehydrogenase; brnQ, branched chain amino acid transporter BrnQ; livJ, Leu/Ile/Val-binding protein; livK, leucine-specific-binding protein; sucAB, alpha-ketoglutarate dehydrogenase; pflB, formate acetyltransferase; ldhA, lactate dehydrogenase A; poxB, pyruvate oxidase

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Biotechnology for Biofuels and Bioproducts

ISSN: 2731-3654

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