Fig. 1
From: Efficient production of mycosporine-like amino acids, natural sunscreens, in Yarrowia lipolytica
Biosynthesis of MAAs A Metabolic pathways for the production of shinorine and porphyra-334 in Y. lipolytica. MAAs are produced from S7P via four enzymatic reactions. Heterologous genes were indicated as blue. B MAA biosynthetic gene clusters of A. variabilis and N. punctiforme used in this study. G6P glucose 6-phosphate, F6P fructose 6-phosphate, G3P glyceraldehyde 3-phosphate, 6PG 6-phosphogluconate, Ru5P ribulose 5-phosphate, R5P ribose 5-phosphate, Xu5P xylulose 5-phosphate, S7P sedoheptulose 7-phosphate, E4P erythrose 4-phosphate, DDG demethyl-4-deoxygadusol, 4-DG 4-deoxygadusol, MG mycosporine-glycine, DDGS DDG synthase, O-MT O-methyltransferase