Fig. 1
From: Minimal aromatic aldehyde reduction (MARE) yeast platform for engineering vanillin production
Schematic diagram of de novo synthesis of vanillin in S. cerevisiae. Colored boxes represent different metabolic routes towards vanillin synthesis. 3DSD 3-dehydroshikimate dehydratase, CAR carboxylic acid reductase, PPTase phosphopantetheine transferase, OMT O-methyltransferase, UbiC chorismate-pyruvate lyase, PobA hydroxybenzoate hydroxylase, HmaS hydroxymandelate synthase, HpaBC two-component flavin-dependent monooxygenase, HMO hydroxymandelate oxidase, BFD benzoylformate decarboxylase, PCA protocatechuate, PCAL protocatechualdehyde, VAN vanillate, HBA hydroxybenzoic acid, HPP hydroxyphenylpyruvate, HMA hydroxymandelate, DHMA 3,4-dihydroxymandelate, DHGA 3,4-dihydroxyphenylglyoxylate, PEP phosphoenolpyruvate, E4P D-erythrose 4-phosphate, DHS 3-dehydroshikimate, SHIK shikimate, SHP shikimate-5-phosphate, CHOR chorismate, EPSP 5-enolpyruvylshikimate-3-phosphate, PREP prephenate