Fig. 5
From: Biosynthesis of melatonin from l-tryptophan by an engineered microbial cell factory
Effect of heterologous pathway on l-Trp metabolism. 5-HTP 5-hydroxytryptophan, 5-HT 5-hydroxytryptamine, NAS N-acetyl-5-hydroxytryptamine, 5-HIAA 5-hydroxyindoleacetic acid, IAM indole-3-acetamide, IAA indole-3-acetic acid, IE tryptophol, ICA indole-3-carboxylic acid, IPyA indole pyruvic acid, ILA indole-3-lactic acid, IPA indole-3-propionic acid, IA indole acrylic acid, KYN kynurenine, KYNA kynurenic acid, 3-HK 3-hydroxykynurenine, AA anthranilic acid, XA xanthurenic acid, NA nicotinic acid. A l-Trp degradation pathway in E. coli. ( →) native pathway, ( →) heterologous pathway. B Heatmap comparing the relative content of L-Trp metabolites between BL5701 and BL7992 with the addition of 1 g/L l-Trp (the darker the blue color, the lower the metabolite content, and the darker the red color, the higher the metabolite content). C The content comparison of the key metabolites between BL5701 and BL7992