Table 1 Physiological function of genes shown in Figure 1 as being required for tolerance to inhibitory concentrations of glucose, ethanol and acetic acid or ethanol, acetic acid and vanillin or furfural.

Anp1

Subunit of the α-1, 6 mannosyltransferase complex involved in the mannysolation of cell wall proteins

Bud31

Protein involved in mRNA splicing

Hpr1

Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export

Pho85

Cyclin-dependent kinase involved in the regulation of yeast response to nutrient depletion, environmental stress and cell cycle progression.

Ppa1

Proteolipid subunit of the membrane domain of the vacuolar H*-ATPase (V-ATPase)

Rpl1B

Component of the large (60S) ribosomal subunit

Vrp1

Actin-associated protein involved in cytoskeletal organization and cytokinesis

Ygl024w

Unknown Function

Stress: Ethanol, acetic acid and vanillin

End3

Protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis

Erg2

Sterol isomerase involved in ergosterol biosynthesis

Erg24

Sterol reductase involved in ergosterol biosynthesis

Gcs1

ADP-ribosylation factor GTPase activating protein, involved in transport from endoplasmic reticulum to Golgi

Rav1

Subunit of the RAVE complex which promotes assembly of the V-ATPase

Tps1

Synthase subunit of trehalose-6-phosphate synthase/phosphatase complex required for trehalose biosynthesis

Stress: Ethanol, acetic acid and furfural

Nat3

Catalytic subunit of the NATB N-terminal acetyltransferase involved in protein acetylation

Ppa1

Proteolipid subunit of the membrane domain of the vacuolar H*-ATPase (V*ATPase)

Rpb4

RNA polymerase II subunit

Prs3

Pyrophosphate synthetase required for nucleotide, histidine and tryptophan biosynthesis

Vma8

Peripheral membrane domain subunit of the vacuolar H+-ATPase (V-ATPase)