Grembecka M. Sugar alcohols-their role in the modern world of sweeteners: a review. Eur Food Res Technol. 2015;241(1):1–14.
Article
CAS
Google Scholar
Werpy T, Petersen G. Top value added chemicals from biomass: volume I—results of screening for potential candidates from sugars and synthesis gas. Golden: National Renewable Energy Lab; 2004.
Livesey G. Health potential of polyols as sugar replacers, with emphasis on low glycaemic properties. Nutr Res Rev. 2007;16(2):163–91.
Article
CAS
Google Scholar
Jagtap S, Rao C. Microbial conversion of xylose into useful bioproducts. Appl Microbiol Biotechnol. 2018;102(21):9015–36.
Article
CAS
PubMed
Google Scholar
Jagtap S, Rao C. Production of d-arabitol from d-xylose by the oleaginous yeast Rhodosporidium toruloides IFO0880. Appl Microbiol Biotechnol. 2018;102(1):143–51.
Article
CAS
PubMed
Google Scholar
Mirończuk A, Biegalska A, Dobrowolski A. Functional overexpression of genes involved in erythritol synthesis in the yeast Yarrowia lipolytica. Biotechnol Biofuels. 2017;10(77):1–12.
Google Scholar
Mirończuk A, Rzechonek D, Biegalska A, Rakicka M, Dobrowolski A. A novel strain of Yarrowia lipolytica as a platform for value-added product synthesis from glycerol. Biotechnol Biofuels. 2016;9(180):1–12.
Google Scholar
Moon H, Jeya M, Kim I, Lee J. Biotechnological production of erythritol and its applications. Appl Microbiol Biotechnol. 2010;86(4):1017–25.
Article
CAS
PubMed
Google Scholar
Pereira I, Madeira A, Prista C, Loureiro-Dias M, Leandro M. Characterization of new polyol/H+ symporters in Debaryomyces hansenii. PLoS ONE. 2014;9(2):e88180.
Article
PubMed
PubMed Central
CAS
Google Scholar
Saha B, Sakakibara Y, Cotta M. Production of d-arabitol by a newly isolated Zygosaccharomyces rouxii. J Ind Microbiol Biotechnol. 2007;34(7):519–23.
Article
CAS
PubMed
Google Scholar
Corma A, Iborra S, Velty A. Chemical routes for the transformation of biomass into chemicals. Chem Rev. 2007;107(6):2411–502.
Article
CAS
PubMed
Google Scholar
Kordowska M. Production of arabitol by yeasts: current status and future prospects. J Appl Microbiol. 2015;119(2):303–14.
Article
CAS
Google Scholar
Rafiqul I, Sakinah A. Processes for the production of xylitol—a review. Food Rev Int. 2013;29(2):127–56.
Article
CAS
Google Scholar
Regnat K, Mach R, Mach-Aigner A. Erythritol as sweetener—wherefrom and whereto? Appl Microbiol Biotechnol. 2018;102(2):587–95.
Article
CAS
PubMed
Google Scholar
Rzechonek D, Dobrowolski A, Rymowicz W, Mirończuk A. Recent advances in biological production of erythritol. Crit Rev Biotechnol. 2018;38(4):620–33.
Article
CAS
PubMed
Google Scholar
Coradetti S, Pinel D, Geiselman G, Ito M, Mondo S, Reilly M, Cheng Y, Bauer S, Grigoriev I, Gladden J, et al. Functional genomics of lipid metabolism in the oleaginous yeast Rhodosporidium toruloides. Elife. 2018;7:e32110.
Article
PubMed
PubMed Central
Google Scholar
Fei Q, O’Brien M, Nelson R, Chen X, Lowell A, Dowe N. Enhanced lipid production by Rhodosporidium toruloides using different fed-batch feeding strategies with lignocellulosic hydrolysate as the sole carbon source. Biotechnol Biofuels. 2016;9(130):1–12.
Google Scholar
Huang X, Liu J, Lu L, Peng K, Yang G, Liu J. Culture strategies for lipid production using acetic acid as sole carbon source by Rhodosporidium toruloides. Bioresour Technol. 2016;206:141–9.
Article
CAS
PubMed
Google Scholar
Wiebe M, Koivuranta K, Penttilä M, Ruohonen L. Lipid production in batch and fed-batch cultures of Rhodosporidium toruloides from 5 and 6 carbon carbohydrates. BMC Biotechnol. 2012;12(26):1–10.
Google Scholar
Zhang S, Ito M, Skerker J, Arkin A, Rao C. Metabolic engineering of the oleaginous yeast Rhodosporidium toruloides IFO0880 for lipid overproduction during high-density fermentation. Appl Microbiol Biotechnol. 2016;100(21):9393–405.
Article
CAS
PubMed
Google Scholar
Zhang S, Skerker J, Rutter C, Maurer M, Arkin A, Rao C. Engineering Rhodosporidium toruloides for increased lipid production. Biotechnol Bioeng. 2015;113(5):1056–66.
Article
PubMed
CAS
Google Scholar
Yaegashi J, Kirby J, Ito M, Sun J, Dutta T, Mirsiaghi M, Sundstrom E, Rodriguez A, Baidoo E, Tanjore D, et al. Rhodosporidium toruloides: a new platform organism for conversion of lignocellulose into terpene biofuels and bioproducts. Biotechnol Biofuels. 2017;10(241):1–13.
Google Scholar
Lee J, Chen L, Cao B, Chen W. Engineering Rhodosporidium toruloides with a membrane transporter facilitates production and separation of carotenoids and lipids in a bi-phasic culture. Appl Microbiol Biotechnol. 2016;100(2):869–77.
Article
CAS
PubMed
Google Scholar
Lee J, Chen L, Shi J, Trzcinski A, Chen W. Metabolomic profiling of Rhodosporidium toruloides grown on glycerol for carotenoid production during different growth phases. J Agric Food Chem. 2014;62(41):10203–9.
Article
CAS
PubMed
Google Scholar
Zhuang X, Kilian O, Monroe E, Ito M, Tran-Gymfi MB, Liu F, Davis R, Mirsiaghi M, Sundstrom E, Pray T, et al. Monoterpene production by the carotenogenic yeast Rhodosporidium toruloides. Microb Cell Fact. 2019;18(54):1–15.
CAS
Google Scholar
Wehrs M, Gladden J, Liu Y, Platz L, Prahl JP, Moon J, Papa G, Sundstrom E, Geiselman G, Tanjore D, et al. Sustainable bioproduction of the blue pigment indigoidine: expanding the range of heterologous products in R. toruloides to include non-ribosomal peptides. Green Chem. 2019;21(12):3394–406.
Article
CAS
Google Scholar
Ageitos J, Vallejo J, Veiga-Crespo P, Villa T. Oily yeasts as oleaginous cell factories. Appl Microbiol Biotechnol. 2011;90(4):1219–27.
Article
CAS
PubMed
Google Scholar
Park Y, Nicaud J, Ledesma-Amaro R. The engineering potential of Rhodosporidium toruloides as a workhorse for biotechnological applications. Trends Biotechnol. 2018;36(3):304–17.
Article
CAS
PubMed
Google Scholar
Zhu Z, Zhang S, Liu H, Shen H, Lin X, Yang F, Zhou Y, Jin G, Ye M, Zou H, et al. A multi-omic map of the lipid-producing yeast Rhodosporidium toruloides. Nat Commun. 2012;3(1112):1–12.
Google Scholar
Dien B, Slininger P, Kurtzman C, Moser B, O’Bryan P. Identification of superior lipid producing lipomyces and myxozyma yeasts. AIMS Environ Sci. 2016;3(1):1–20.
Article
CAS
Google Scholar
Natarajan J, Madras G, Chatterjee K. Development of graphene oxide-/galactitol polyester-based biodegradable composites for biomedical applications. ACS Omega. 2017;2(9):5545–56.
Article
CAS
PubMed
PubMed Central
Google Scholar
Natarajan J, Movva S, Madras G, Chatterjee K. Biodegradable galactitol based crosslinked polyesters for controlled release and bone tissue engineering. Mater Sci Eng C Mater Biol Appl. 2017;77:534–47.
Article
CAS
PubMed
Google Scholar
Clark J, Livesey J, Steele J. Delay or inhibition of rat lens opacification using pantethine and WR-77913. Exp Eye Res. 1996;62(1):75–84.
Article
CAS
PubMed
Google Scholar
Jiang X, Huang Y, Wang X, Liang Q, Li Y, Li F, Fu X, Huang C, Liu H. Dianhydrogalactitol, a potential multitarget agent, inhibits glioblastoma migration, invasion, and angiogenesis. Biomed Pharmacother. 2017;91:1065–74.
Article
CAS
PubMed
Google Scholar
Kamada M, Satoh T, Yokota K, Kakuchi T. Regio- and stereoselective cyclopolymerization of 1,2:5,6-dianhydroallitol and 1,2:5,6-dianhydrogalactitol leading to a novel carbohydrate polymer of (2 → 6)-1,5-anhydro-dl-galactitol. Macromolecules. 1999;32(18):5755–9.
Article
CAS
Google Scholar
Zhang X, Lian Y, Guo W, Xu B, Li M, Zhou Y, Rong C. Anticancer activity and mechanisms of diacetyldianhydrogalactitol on hepatoma QGY-7703 cells. Anticancer Drug. 2009;20(10):926–31.
Article
CAS
Google Scholar
Caputto R, Leloir L, Trucco R, Cardini C, Paladini A. The enzymatic transformation of galactose into glucose derivatives. J Biol Chem. 1949;179(1):497–8.
CAS
PubMed
Google Scholar
Lazar Z, Gamboa-Meléndez H, Coq A, Neuvéglise C, Nicaud J. Awakening the endogenous Leloir pathway for efficient galactose utilization by Yarrowia lipolytica. Biotechnol Biofuels. 2015;8(185):1–16.
Google Scholar
Meyer J, Walker J, Hollenberg C. Galactokinase encoded by GAL1 is a bifunctional protein required for induction of the GAL genes in Kluyveromyces lactis and is able to suppress the gal3 phenotype in Saccharomyces cerevisiae. Mol Cell Biol. 1991;11(11):5454–61.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sellick C, Campbell R, Reece R. Galactose metabolism in yeast-structure and regulation of the Leloir pathway enzymes and the genes encoding them. Int Rev Cell Mol Biol. 2008;269:111–50.
Article
CAS
PubMed
Google Scholar
Zaman S, Lippman S, Zhao X, Broach J. How Saccharomyces responds to nutrients. Annu Rev Genet. 2008;42:27–81.
Article
CAS
PubMed
Google Scholar
Gancedo J. Yeast carbon catabolite repression. Microbiol Mol Biol Rev. 1998;62(2):334–61.
CAS
PubMed
PubMed Central
Google Scholar
Kuhn A, Zyl C, Tonder A, Prior B. Purification and partial characterization of an aldo-keto reductase from Saccharomyces cerevisiae. Appl Environ Microbiol. 1995;61(4):1580–5.
CAS
PubMed
PubMed Central
Google Scholar
Liu J, Zhang G, Kong I, Yun E, Zheng J, Kweon D, Jin Y. A Mutation in PGM2 causing inefficient galactose metabolism in the probiotic yeast Saccharomyces boulardii. Appl Environ Microbiol. 2018;84(10):e02858-17.
Article
PubMed
PubMed Central
Google Scholar
Petrash J. All in the family: aldose reductase and closely related aldo-keto reductases. Cell Mol Life Sci. 2004;61(7):737–49.
Article
CAS
PubMed
Google Scholar
de Jongh W, Bro C, Ostergaard S, Regenberg B, Olsson L, Nielsen J. The roles of galactitol, galactose-1-phosphate, and phosphoglucomutase in galactose-induced toxicity in Saccharomyces cerevisiae. Biotechnol Bioeng. 2008;101(2):317–26.
Article
PubMed
CAS
Google Scholar
Los E, Ford G. Galactose-1-phosphate uridyltransferase deficiency (galactosemia). In: StatPearls. StatPearls Publishing. 2017.
Muniruzzaman S, Itoh H, Yoshino A, Katayama T, Izumori K. Biotransformation of lactose to galactitol. J Ferment Bioeng. 1994;77(1):32–5.
Article
CAS
Google Scholar
Onishi H, Suzuki T. Formation of dulcitol in aerobic dissimilation of d-galactose by yeasts. J Bacteriol. 1968;95(5):1745–9.
CAS
PubMed
PubMed Central
Google Scholar
Masuda C, Previato J, Miranda M, Assis L, Penha L, Mendonça-Previato L, Montero-Lomelí M. Overexpression of the aldose reductase GRE3 suppresses lithium-induced galactose toxicity in Saccharomyces cerevisiae. FEMS Yeast Res. 2008;8(8):1245–53.
Article
CAS
PubMed
Google Scholar
Yun E, Oh E, Liu J, Yu S, Kim D, Kwak S, Kim K, Jin Y. Promiscuous activities of heterologous enzymes lead to unintended metabolic rerouting in Saccharomyces cerevisiae engineered to assimilate various sugars from renewable biomass. Biotechnol Biofuels. 2018;11(140):1–14.
Google Scholar
Liu J, Zhang G, Kwak S, Oh E, Yun E, Chomvong K, Cate J, Jin Y. Overcoming the thermodynamic equilibrium of an isomerization reaction through oxidoreductive reactions for biotransformation. Nat Commun. 2019;10(1356):1–8.
Google Scholar
Izard J, Limberger R. Rapid screening method for quantitation of bacterial cell lipids from whole cells. J Microbiol Methods. 2003;55(2):411–8.
Article
CAS
PubMed
Google Scholar
Quarterman J, Slininger P, Kurtzman C, Thompson S, Dien B. A survey of yeast from the Yarrowia clade for lipid production in dilute acid pretreated lignocellulosic biomass hydrolysate. Appl Microbiol Biotechnol. 2017;101(8):3319–34.
Article
CAS
PubMed
Google Scholar
Lepage G, Roy C. Direct transesterification of all classes of lipids in a one-step reaction. J Lipid Res. 1986;27(1):114–20.
CAS
PubMed
Google Scholar
Kim S, Lee D, Wohlgemuth G, Park H, Fiehn O, Kim K. Evaluation and optimization of metabolome sample preparation methods for Saccharomyces cerevisiae. Anal Chem. 2013;85(4):2169–76.
Article
CAS
PubMed
Google Scholar
Stein S. An integrated method for spectrum extraction and compound identification from gas chromatography/mass spectrometry data. J Am Soc Mass Spectrom. 1999;10(8):770–81.
Article
CAS
Google Scholar
Kopka J, Schauer N, Krueger S, Birkemeyer C, Usadel B, Bergmüller E, Dörmann P, Weckwerth W, Gibon Y, Stitt M, et al. GMD@CSB.DB: the Golm Metabolome Database. Bioinformatics. 2005;21(8):1635–8.
Article
CAS
PubMed
Google Scholar
Styczynski M, Moxley J, Tong L, Walther J, Jensen K, Stephanopoulos G. Systematic identification of conserved metabolites in GC/MS data for metabolomics and biomarker discovery. Anal Chem. 2007;79(3):966–73.
Article
CAS
PubMed
Google Scholar
Metsalu T, Vilo J. ClustVis: a web tool for visualizing clustering of multivariate data using principal component analysis and heatmap. Nucleic Acids Res. 2015;43(W1):W566–70.
Article
CAS
PubMed
PubMed Central
Google Scholar