Ajikumar PK, Tyo K, Carlsen S, Mucha O, Phon TH, Stephanopoulos G. Terpenoids: opportunities for biosynthesis of natural product drugs using engineered microorganisms. Mol Pharm. 2008;5:167.
Das A, Yoon SH, Lee SH, Kim JY, Oh DK, Kim SW. An update on microbial carotenoid production: application of recent metabolic engineering tools. Appl Microbiol Biotechnol. 2007;77:505–12.
Schmidtdannert C. Engineering novel carotenoids in microorganisms. Curr Opin Biotechnol. 2000;11:255.
Doshi R, Nguyen T, Chang G. Transporter-mediated biofuel secretion. Proc Natl Acad Sci USA. 2013;110:7642–7.
Meckel RA, Kester AS. Extractability of carotenoid pigments from nonphotosynthetic bacteria with solvents and detergents: implications for the location and binding of the pigments. Microbiology. 1980;120:111–6.
Mathews MM, Sistrom WR. Intracellular location of carotenoid pigments and some respiratory enzymes in Sarcina lutea. J Bacteriol. 1959;78:778–87.
Farhi M, Marhevka E, Masci T, Marcos E, Eyal Y, Ovadis M, Abeliovich H, Vainstein A. Harnessing yeast subcellular compartments for the production of plant terpenoids. Metab Eng. 2011;13:474–81.
Avalos JL, Fink GR, Stephanopoulos G. Compartmentalization of metabolic pathways in yeast mitochondria improves the production of branched-chain alcohols. Nat Biotechnol. 2013;31:335–41.
Lv X, Wang F, Zhou P, Ye L, Xie W, Xu H, Yu H. Dual regulation of cytoplasmic and mitochondrial acetyl-CoA utilization for improved isoprene production in Saccharomyces cerevisiae. Nat Commun. 2016;7:12851.
Dueber JE, Wu GC, Malmirchegini GR, Moon TS, Petzold CJ, Ullal AV, Prather KL, Keasling JD. Synthetic protein scaffolds provide modular control over metabolic flux. Nat Biotechnol. 2009;27:753–9.
Lee MJ, Mantell J, Hodgson L, Alibhai D, Fletcher JM, Brown IR, Frank S, Xue WF, Verkade P, Woolfson DN, Warren MJ. Engineered synthetic scaffolds for organizing proteins within the bacterial cytoplasm. Nat Chem Biol. 2018;14:142–7.
Conrado RJ, Wu GC, Boock JT, Xu H, Chen SY, Lebar T, Turnsek J, Tomsic N, Avbelj M, Gaber R, et al. DNA-guided assembly of biosynthetic pathways promotes improved catalytic efficiency. Nucleic Acids Res. 2012;40:1879–89.
Zhu LY, Qiu XY, Zhu LY, Wu XM, Zhang Y, Zhu QH, Fan DY, Zhu CS, Zhang DY. Spatial organization of heterologous metabolic system in vivo based on TALE. Sci Rep. 2016;6:26065.
Myhrvold C, Polka JK, Silver PA. Synthetic lipid-containing scaffolds enhance production by colocalizing enzymes. ACS Synth Biol. 2016;5:1396–403.
Choudhary S, Quin MB, Sanders MA, Johnson ET, Schmidt-Dannert C. Engineered protein nano-compartments for targeted enzyme localization. PLoS ONE. 2012;7:e33342.
Jakobson CM, Slininger Lee MF, Tullman-Ercek D. De novo design of signal sequences to localize cargo to the 1,2-propanediol utilization microcompartment. Protein Sci. 2017;26:1086–92.
Rodriguez-Bustamante E, Sanchez S. Microbial production of C13-norisoprenoids and other aroma compounds via carotenoid cleavage. Crit Rev Microbiol. 2007;33:211–30.
Lopez J, Essus K, Kim IK, Pereira R, Herzog J, Siewers V, Nielsen J, Agosin E. Production of beta-ionone by combined expression of carotenogenic and plant CCD1 genes in Saccharomyces cerevisiae. Microb Cell Fact. 2015;14:84.
Rubio A, Rambla JL, Santaella M, Gomez MD, Orzaez D, Granell A, Gomez-Gomez L. Cytosolic and plastoglobule-targeted carotenoid dioxygenases from Crocus sativa are both involved in beta-ionone release. J Biol Chem. 2008;283:24816–25.
Frusciante S, Diretto G, Bruno M, Ferrante P, Pietrella M, Prado-Cabrero A, Rubio-Moraga A, Beyer P, Gomez-Gomez L, Al-Babili S. Novel carotenoid cleavage dioxygenase catalyzes the first dedicated step in saffron crocin biosynthesis. Proc Natl Acad Sci USA. 2014;111:12246–51.
Artimo P, Jonnalagedda M, Arnold K, Baratin D, Csardi G, de Castro E, Duvaud S, Flegel V, Fortier A, Gasteiger E, et al. ExPASy: SIB bioinformatics resource portal. Nucleic Acids Res. 2012;40:W597–603.
Wu T, Ye L, Zhao D, Li S, Li Q, Zhang B, Bi C, Zhang X. Membrane engineering—a novel strategy to enhance the production and accumulation of beta-carotene in Escherichia coli. Metab Eng. 2017;43:85–91.
Lee PC, Schmidt-Dannert C. Metabolic engineering towards biotechnological production of carotenoids in microorganisms. Appl Microbiol Biotechnol. 2002;60:1–11.
Nishida Y, Adachi K, Kasai H, Shizuri Y, Shindo K, Sawabe A, Komemushi S, Miki W, Misawa N. Elucidation of a carotenoid biosynthesis gene cluster encoding a novel enzyme, 2,2′-beta-hydroxylase, from Brevundimonas sp. strain SD212 and combinatorial biosynthesis of new or rare xanthophylls. Appl Environ Microbiol. 2005;71:4286–96.
Choi SK, Nishida Y, Matsuda S, Adachi K, Kasai H, Peng X, Komemushi S, Miki W, Misawa N. Characterization of beta-carotene ketolases, CrtW, from marine bacteria by complementation analysis in Escherichia coli. Mar Biotechnol (NY). 2005;7:515–22.
Scaife MA, Burja AM, Wright PC. Characterization of cyanobacterial beta-carotene ketolase and hydroxylase genes in Escherichia coli, and their application for astaxanthin biosynthesis. Biotechnol Bioeng. 2009;103:944–55.
Zhao J, Li Q, Sun T, Zhu X, Xu H, Tang J, Zhang X, Ma Y. Engineering central metabolic modules of Escherichia coli for improving β-carotene production. Metab Eng. 2013;17:42–50.
Hillson NJ, Rosengarten RD, Keasling JD. j5 DNA assembly design automation software. ACS Synth Biol. 2012;1:14–21.
Engler C, Marillonnet S. Generation of families of construct variants using golden gate shuffling. Methods Mol Biol. 2011;729:167–81.
Liang J, Chao R, Abil Z, Bao Z, Zhao H. FairyTALE: a high-throughput TAL effector synthesis platform. ACS Synth Biol. 2014;3:67–73.
Fu D, Libson A, Miercke LJW, Weitzman C, Nollert P, Krucinski J, Stroud RM. Structure of a glycerol-conducting channel and the basis for its selectivity. Science. 2000;290:481–6.
Neophytou I, Harvey R, Lawrence J, Marsh P, Panaretou B, Barlow D. Eukaryotic integral membrane protein expression utilizing the Escherichia coli glycerol-conducting channel protein (GlpF). Appl Microbiol Biotechnol. 2007;77:375–81.
Raran-Kurussi S, Keefe K, Waugh DS. Positional effects of fusion partners on the yield and solubility of MBP fusion proteins. Protein Expr Purif. 2015;110:159–64.
Yamabhai M, Emrat S, Sukasem S, Pesatcha P, Jaruseranee N, Buranabanyat B. Secretion of recombinant Bacillus hydrolytic enzymes using Escherichia coli expression systems. J Biotechnol. 2008;133:50–7.
Hulisz DT, Boles GL. Clinical review of canthaxanthin (6Tanning Pills’): before recommending this product for tanning long-term safety must be established. Am Pharm. 1993;33:44–6.
Ma L, Yan SF, Huang YM, Lu XR, Qian F, Pang HL, Xu XR, Zou ZY, Dong PC, Xiao X. Effect of lutein and zeaxanthin on macular pigment and visual function in patients with early age-related macular degeneration. Ophthalmology. 2012;119:2290–7.
Palozza P, Maggiano N, Calviello G, Lanza P, Piccioni E, Ranelletti FO, Bartoli GM. Canthaxanthin induces apoptosis in human cancer cell lines. Carcinogenesis. 1998;19:373.
Zhao L, Sweet BV. Lutein and zeaxanthin for macular degeneration. Am J Health-Syst Pharm. 2008;65:1232.